Comparative toxicity of chloroquine and bis[(chloro-7″-quinolyl-4″)-amino-2′ propyl]-1,4-piperazine (WR 3863)

Comparative toxicity of chloroquine and bis[(chloro-7″-quinolyl-4″)-amino-2′ propyl]-1,4-piperazine (WR 3863)

Source :

• Toxicology and Applied Pharmacology [ 0041-008X ] ; 1969.

Descripteurs français

• KwdFr :
  • Animaux, Animaux nouveau-nés (), Antipaludiques (usage thérapeutique), Aorte (), Artère pulmonaire (), Atrium du coeur (), Chats, Chiens, Chloroquine (toxicité), Coeur (), Contraction musculaire (), Débit cardiaque (), Myocarde (enzymologie), Paludisme (traitement médicamenteux), Pipérazines (toxicité), Plasmodium (), Poumon (physiologie), Pression sanguine (), Rats, Souris.
• MESH :
  • enzymologie : Myocarde.
  • physiologie : Poumon.
  • toxicité : Chloroquine, Pipérazines.
  • traitement médicamenteux : Paludisme.
  • usage thérapeutique : Antipaludiques.
  • Animaux, Animaux nouveau-nés, Aorte, Artère pulmonaire, Atrium du coeur, Chats, Chiens, Coeur, Contraction musculaire, Débit cardiaque, Plasmodium, Pression sanguine, Rats, Souris.

English descriptors

• KwdEn :
  • Animals, Animals, Newborn (drug effects), Antimalarials (therapeutic use), Aorta (drug effects), Blood Pressure (drug effects), Cardiac Output (drug effects), Cats, Chloroquine (toxicity), Dogs, Heart (drug effects), Heart Atria (drug effects), Lung (physiology), Malaria (drug therapy), Mice, Muscle Contraction (drug effects), Myocardium (enzymology), Piperazines (toxicity), Plasmodium (drug effects), Pulmonary Artery (drug effects), Rats.
• MESH :
  • chemical , therapeutic use : Antimalarials.
  • drug effects : Animals, Newborn, Aorta, Blood Pressure, Cardiac Output, Heart, Heart Atria, Muscle Contraction, Plasmodium, Pulmonary Artery.
  • drug therapy : Malaria.
  • enzymology : Myocardium.
  • physiology : Lung.
  • chemical , toxicity : Chloroquine, Piperazines.
• Teeft :
  • Anesthetized, Animal species, Animals, Antimalarial, Antimalarial activity, Antimalarial potency, Aortic, Aortic blood pressure, Atria1, Atria1 muscle, Aviado, Bellet, Berghei, Blood pressure, Cardiac, Cardiac output, Cardiovascular effects, Cats, Chloroquine, Common carotid, Concurrent administration, Continuous infusion, Contractility, Control control control, Dmso, Dogs, Dos, Enzyme activity, Femoral artery, Folic, Folic acid, Intravenous injection, Intravenous injections, Lethal dose, Lethal doses, Mice, Mouse heart homogenate, Myocardial contractility, Normal mice, Optical density, Other hand, Pulmonary artery, Pulmonary compliance, Pulmonary resistance, Quantitative comparison, Rats, Respiratory enzyme activity, Smooth muscles, Statham transducer, Threshold voltage, Tidal volume, Toxicity, Variable effect.

Abstract

• https://api.istex.fr/ark:/67375/6H6-SQPX92V1-T/fulltext.pdf

Affiliations:

• États-Unis
• Pennsylvanie

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